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Lead Optimization Service

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Lead optimization is the complex, iterative process of altering the chemical structure of a confirmed hit to identify an improved drug lead with the goal of progressing to a preclinical candidate.
Once AMRI chemists identify a screening hit, its world-class medicinal chemistry department provides lead optimization services. Well-trained, intuitive and knowledgeable, AMRI’s medicinal chemists have years of experience working with drug-like compounds. AMRI complements its medicinal chemistry lead optimization expertise with technologies in metabolism and biotransformation, including proprietary combinatorial biocatalysis technology and extensive fermentation capabilities.
All of AMRI’s scientists are well-trained in analytical techniques, and its on-site analytical department provides all of the necessary support to keep your compounds moving quickly through the discovery pipeline.

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