Physical properties of a molecular entity can vary greatly depending on the solid form (salt, co-crystal, amorphous dispersion or crystalline polymorph).
Optimization and identification of available solid forms provides an opportunity to overcome physical property challenges or potential form control issues by identifying more promising alternatives. Screening and selection of appropriate solid forms early in development provide a basis for consistent production and performance while reducing costs associated with toxicological bridging studies or further process development efforts.
AMRI provides a comprehensive array of solid form screening services to select the most appropriate solid forms for intermediates and drug substances. Given the different requirements of drug indication, stage of development, intended formulation or storage conditions, AMRI works with you to customize investigations to identify the most appropriate forms for desired physical properties and controlled scale-up.