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Vitro Admet Assays Service

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AMRI conducts in vitro ADMET assays to evaluate and improve metabolism, bioavailability, pharmacology and toxicology of compounds.
Early stage ADMET testing, integrated with Medicinal Chemistry programs, typically include:
* Aqueous solubility under physiological conditions
* Metabolic and chemical stability
* Membrane permeability (PAMPA, Caco-2, etc.)
* Inhibition of major metabolic enzymes (CYP450s)
Additional ADMET studies include numerous analytical services, as well as:
* Metabolite profiling
* Metabolite mass balance and isolation from urine, blood, feces, etc.
* Metabolite structure elucidation
* Metabolite synthesis
* Animal species selection
* CYP phenotyping
* Induction of major CYP isoforms
* Enhanced PAMPA & cell-based permeability models
* Plasma protein binding
* Cytotoxicity assays against human cell lines
* Reactive metabolite evaluation
* Time-dependent inhibition of CYP isoforms
* Ames Tests for mutagenicity
* Tissue and biological fluid extractions
* Bioanalytical Method Development
* Bioanalytical Studies


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