Brevetti Angela

SYFPAC® is an acronym for “System for Filling Parenterals Aseptically into Containers of plastic materials”, while SVP stands for “Small Volume Parenterals.” SYFPAC® SVP machine designed specifically for containers which has filled volume between 0,2 ml up to 50 ml, for aseptic primary packaging of: Injectable solutions, ophthalmological preparations, ear drops, preparation for aerosol therapy, respules, disinfectants, diluents, antibiotics and solutions for reconstitution. Special systems can be developed for filling systems to package pastes, creams, thixotropic substances, suspensions, substances which sets very quickly, substances which needs protection from light and from atmospheric oxygen. Temperature of the liquid while filling should be typically between 4°C to 30°C. Modified systems can be developed to handle liquids at higher temperature. Small volume container made from plastic using BFS technology presents several advantages compared to conventional glass ampoules and vials. Plastic containers are much more convenient and safe to use as they are shatter proof and when opened, do not expose sharp edges. These containers being light weight and virtually unbreakable, can be transported with ease without any loss during transportation. In most of the case either PE or PP is mainly used for making these containers and both the materials are non toxic and compatible with several pharmaceutical substance in accordance with pharmacopoeia. Both PP and PE are recyclable and environment friendly. Plastic during moulding permits to make intricate shapes and forms, as a result opening and head shape can be customised for different application. For example: Luer Lock or Luer fit type of container allows for a connection and the direct withdrawal of the product by syringe. Containers with long and narrow nozzle with twist off can be used for Eye and or Ear drops Calibrated drops can be dispensed using plastic inserts before closure. Special reclosable twist off head allows re use of the container. Multi dose containers can be made using threaded head to fit a cap. Use of single use eye and Ear drop, aerosol, and injectable is becoming more and more popular. Most of these single use containers are made using BFS technology.