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Immunoglobulins

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The quantification of serum immunoglobulins is a vital first-line test in the investigation of Primary Immunodeficiency.1 The results are often the basis for further investigative testing such as antibody function. IgG, IgA and IgM concentrations can be measured reliably by a wide range of laboratory assays and are a useful screening method for the detection of agammaglobulinaemia and hypogammaglobulinaemia.

Selective IgA deficiency is the most common antibody deficiency. It can be defined as a serum IgA level of less than 0.07g/L (and normal IgG and IgM levels) in a patient older than 4 years.2,3

All Binding Site immunoglobulin assays are calibrated to the International Reference Preparation CRM470. This ensures that sample results remain accurate and consistent.

The quantitation of IgD in serum samples is an important part in the diagnosis and monitoring of PID. Hyper-IgD syndrome has been described as a consideration in phagocyte deficiencies4 and IgD levels are also increased in periodic fever syndrome.

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